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Wham is designed for paired-stop Illumina libraries with typical insert dimensions (~300bp-500bp). Wham integrates mate-pair mapping, break up go through mapping, gentle-clipping, choice alignment and consensus sequence dependent evidence to predict SV breakpoints with one-nucleotide accuracy. Wham generates a put together pileup (catalog of reads
The comfortable-clipped sequences that overhang the breakpoint are collapsed into a consensus sequence using a various sequence alignment (MSA) delivered within the seqAn library [27]. Wham applies three filters to the consensus sequences. Breakpoints aren't documented in instances the place consensus sequences are shorter than ten bp or incorporat
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